AI Article Synopsis
- The study investigates the potential link between congenital heart disease (CHD) and an increased risk of developing cancer, utilizing a meta-analysis approach to analyze existing research.
- A total of six studies, involving over 276,000 participants, found that patients with CHD have a significantly higher hazard risk for cancer, with a pooled hazard risk of 1.71, indicating they are 71% more likely to develop cancer.
- The research underscores the need for cancer prevention strategies and health education specifically targeting CHD patients, while also calling for further studies to better quantify the cancer risk in this population.
Article Abstract
Introduction: There has been remarkable progress in both diagnosis and treatment of patients with congenital heart disease (CHD), with an increasing number of survivors. Whether patients with CHD are more likely to develop cancer is still a controversial issue. This study aimed to quantitatively estimate the association between patients with CHD and the risk of developing cancer through meta-analysis.
Methods: Web of Science, PubMed, and Embase databases were searched from inception to September 2023 to identify potentially relevant case-control studies and cohort studies that reported risk estimates and confidence intervals (CIs). RevMan software was used to analyze the pooled effect size and test for heterogeneity. The random effect and fixed effect models were applied to the study period. Egger's test was performed to examine publication bias.
Results: We analyzed six studies, consisting of 2 case-control studies and 4 cohort studies comprising 276,124 participants. The overall pooled hazard risk for cancer in patients with CHD was 1.71 (95% CI: 1.28-2.28; p < 0.01), with significant heterogeneity (I2 = 97%, p < 0.01). The quantitative analysis of studies indicates that patients with CHD have an increased risk of developing cancer, even after adjusting for chromosomal disorders.
Conclusion: Our study highlights the importance of controlling modifiable factors in cancer prevention and emphasizes the need for health education for patients with CHD in primary care. Given the limited number of studies included in this analysis, further research is needed to accurately quantify the cancer risk of exposed versus unexposed CHD.
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| http://dx.doi.org/10.1159/000540443 | DOI Listing |
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