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Free water-corrected fractional anisotropy of the fornix and parahippocampal cingulum predicts longitudinal memory change in cognitively healthy older adults. | LitMetric

AI Article Synopsis

  • Prior research found mixed results on how the fornix and parahippocampal cingulum relate to memory performance and changes over time.
  • This study investigated these relationships in cognitively healthy older adults, revealing that baseline measures of these brain structures did not correlate with initial memory performance.
  • However, higher integrity of the fornix and cingulum was linked to less decline in memory over three years, indicating that these metrics are useful predictors of memory changes in older adults, particularly when accounting for free water in imaging analysis.

Article Abstract

Prior studies have reported inconsistent results regarding the relationships between the integrity of the fornix and parahippocampal cingulum and both memory performance and longitudinal change in performance. In the present study, we examined associations in a sample of cognitively healthy older adults between free water-corrected fractional anisotropy (FA) metrics derived from the fornix and cingulum, baseline memory performance, and 3-year memory change. Neither fornix nor cingulum FA correlated with memory performance at baseline. By contrast, FA of each tract was predictive of memory change, such that greater FA was associated with less longitudinal decline. These associations remained significant after controlling for FA of other white matter tracts and for performance in other cognitive domains. Furthermore, fornix and cingulum FA explained unique variance in memory change. These results suggest that free water-corrected measures of fornix and parahippocampal cingulum integrity are reliable predictors of future memory change in cognitively healthy older adults. The findings for the fornix in particular highlight the utility of correcting for free water when estimating diffusion tensor imaging metrics of white matter integrity.

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Source
http://dx.doi.org/10.1016/j.neurobiolaging.2024.04.005DOI Listing

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