AI Article Synopsis
- Near-tetraploidy/tetraploidy (NT/T) is a genetic change found in acute myeloid leukemia (AML), which affects prognosis and is more prevalent in older males with specific blood abnormalities.
- A study revealed that 77.8% of NT/T AML cases showed dysgranulopoiesis, and most patients had multiple genetic abnormalities, with a significant portion exhibiting NT/T as the only abnormality.
- Among those treated for NT/T AML, 80% reached complete remission, but the overall survival rate was low, with a median of just 4.5 months.
Article Abstract
Near-tetraploidy/tetraploidy (NT/T) is a cytogenetic alteration in acute myeloid leukemia (AML). In AML, specific chromosomal alterations are associated with clinical, morphological, and immunophenotypic features. The impact of cytogenetics on the prognosis of AML is well established. However, the prognostic implication of NT/T on AML remains unclear. Our aim is to further characterize the clinical, morphologic, immunophenotypic, molecular mutational, and prognostic features of NT/T AML. This retrospective chart review of NT/T AML cases showed NT/T AML was more common in older adult males, with predominately large blasts and myelodysplasia-related features. The most common lineage of dysplasia was dysgranulopoiesis in 77.8% of cases. Cases displayed multiple cytogenetic abnormalities, with only four showing NT/T as the sole abnormality was the most common molecular mutation associated with NT/T AML (44.5%). Of the patients receiving treatment for NT/T AML, 80% achieved a CR. The median overall survival for the entire cohort was 4.5 months.
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| http://dx.doi.org/10.1080/10428194.2024.2382923 | DOI Listing |
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