AI Article Synopsis
- - This study investigates how sex differences impact the functional network organization in individuals with autism spectrum disorder (ASD) by comparing 86 females with ASD to 86 typically developing controls (TCs) using brain imaging data.
- - Results showed that females with ASD had higher cluster coefficient and local efficiency compared to female TCs, while no significant differences were found in males, suggesting that females may process information differently in ASD.
- - Additionally, typical sex differences in network metrics seen in TCs were absent in those with ASD, highlighting a unique abnormality in brain function, particularly in the left middle temporal gyrus for those with ASD.
Article Abstract
Although numerous studies have emphasized the male predominance in autism spectrum disorder (ASD), how sex differences are related to the topological organization of functional networks remains unclear. This study utilized imaging data from 86 ASD (43 females, aged 7-18 years) and 86 typically developing controls (TCs) (43 females, aged 7-18 years) obtained from Autism Brain Imaging Data Exchange databases, constructed individual whole-brain functional networks, used a graph theory analysis to compute topological metrics, and assessed sex-related differences in topological metrics using a 2 × 2 factorial design. At the global level, females with ASD exhibited significantly higher cluster coefficient and local efficiency than female TCs, while no significant difference was observed between males with ASD and male TCs. Meanwhile, the neurotypical sex differences in cluster coefficient and local efficiency observed in TCs were not present in ASD. At the nodal level, ASD exhibited abnormal nodal centrality in the left middle temporal gyrus.
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| http://dx.doi.org/10.1002/aur.3180 | DOI Listing |
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