AI Article Synopsis
- Cutaneous inflammation is a shared characteristic found in several systemic autoimmune rheumatic diseases (SARDs), particularly systemic lupus erythematosus, undifferentiated connective tissue disease, mixed connective tissue disease, and dermatomyositis, while it’s less common in primary Sjögren's syndrome.
- Understanding whether the underlying processes of skin inflammation in these diseases are similar or distinct is crucial for the development of targeted treatments.
- This review will explore the similarities and differences in inflammatory skin diseases across SARDs, emphasizing histopathology and highlighting recent advancements from single-cell technologies.
Article Abstract
Cutaneous inflammation is a common feature of several systemic autoimmune rheumatic diseases (SARDs) including systemic lupus erythematosus (SLE), undifferentiated connective tissue disease (UCTD), mixed connective tissue disease (MCTD) and dermatomyositis (DM) but is less common in other SARDs such as primary Sjögren's syndrome (pSS). It is important to understand whether the pathophysiological processes underlying skin inflammation are different or shared between SARDs to develop targeted therapies. This review will discuss commonalities and differences between inflammatory skin disease in SARDs focusing on histopathology and describe newer insights obtained from single-cell technologies.
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| http://dx.doi.org/10.55563/clinexprheumatol/8vvgva | DOI Listing |
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