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Causal relationships involving brain imaging-derived phenotypes based on UKB imaging cohort: a review of Mendelian randomization studies. | LitMetric

AI Article Synopsis

  • The UK Biobank (UKB) is a major resource for brain imaging research, with over 40,000 participants contributing to a large dataset used in Mendelian randomization studies aimed at establishing causal relationships.
  • A systematic review identified 34 studies published before December 2023, demonstrating connections between various lifestyle factors, diseases, and brain image-derived phenotypes (BIDPs).
  • Findings showed that lifestyle habits like alcohol and coffee consumption, along with diseases such as Alzheimer's and cardiovascular conditions, are causally linked to BIDPs, which may also act as mediators in the relationship between inactivity and major depressive disorder.

Article Abstract

The UK Biobank (UKB) has the largest adult brain imaging dataset, which encompasses over 40,000 participants. A significant number of Mendelian randomization (MR) studies based on UKB neuroimaging data have been published to validate potential causal relationships identified in observational studies. Relevant articles published before December 2023 were identified following the PRISMA protocol. Included studies ( = 34) revealed that there were causal relationships between various lifestyles, diseases, biomarkers, and brain image-derived phenotypes (BIDPs). In terms of lifestyle habits and environmental factors, there were causal relationships between alcohol consumption, tea intake, coffee consumption, smoking, educational attainment, and certain BIDPs. Additionally, some BIDPs could serve as mediators between leisure/physical inactivity and major depressive disorder. Regarding diseases, BIDPs have been found to have causal relationships not only with Alzheimer's disease, stroke, psychiatric disorders, and migraine, but also with cardiovascular diseases, diabetes, poor oral health, osteoporosis, and ankle sprain. In addition, there were causal relationships between certain biological markers and BIDPs, such as blood pressure, LDL-C, IL-6, telomere length, and more.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11266110PMC
http://dx.doi.org/10.3389/fnins.2024.1436223DOI Listing

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