AI Article Synopsis
- This study investigates the causes and prevalence of specific pathogens in endophthalmitis patients at a hospital in Southwest China over a 9-year period, aiming to understand how environmental factors affect the disease.
- Data from 2,712 fungal or bacterial strains shows that gram-positive bacteria are the most common culprits, with a notable resistance to levofloxacin compared to moxifloxacin, and trauma being the leading cause of infections.
- The research highlights the importance of the identified pathogen in endophthalmitis and warns against using levofloxacin as a first-line treatment, noting that changes in metabolites can indicate a shift towards a more harmful pathogenic state under low oxygen conditions.
Article Abstract
Introduction: This study aims to delineate the etiology and prevalence of isolated pathogens, along with the clinical characteristics of endophthalmitis patients over a 9-year period at hospital in Southwest of China. Additionally, we investigating the metabolic and cellular processes related to environmental factors may offer novel insights into endophthalmitis.
Methods: We analyzed data pertaining to endophthalmitis patients treated at the Affiliated Hospital of Yunnan University from 2015 to 2023. According to our clinical data, we conducted an experiment based on transcriptomics and metabolomics analysis to verify whether environmental factors affect behavior of by culturating under oxic and microoxic condition.
Results: In this study, 2,712 fungi or bacteria strains have been analyzed, gram-positive bacteria constituted 65.08%, with being the most predominant species (25.55%). Ophthalmic trauma was the primary pathogenic factor for ocular infections. Regarding fluoroquinolones, exhibited the higher resistance rate to levofloxacin than moxifloxacin. Moreover, our investigation revealed that in microoxic environment increase in energy metabolism, amino acid metabolism, and membrane transport.
Conclusion: Our findings underscore the significance of as a crucial pathogen responsible for infectious endophthalmitis. It is crucial to exercise vigilance when considering Levofloxacin as the first-line drug for empiric endophthalmitis treatment. The metabolites alteration observed during the commensal-to-pathogen conversion under microoxic condition serve as a pivotal environmental signal contributing to metabolism remodeling, toward more pathogenic state.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11266177 | PMC |
| http://dx.doi.org/10.3389/fmicb.2024.1409597 | DOI Listing |
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