AI Article Synopsis
- Anaplastic large T/null cell lymphoma (ALCL) is an aggressive type of non-Hodgkin's lymphoma most commonly seen in young men, and a case study presents a 32-year-old male with severe symptoms including ulcerated adenopathy and sepsis.
- Diagnosis was confirmed through a bone marrow biopsy and immunohistochemical tests showed specific markers indicating ALCL presence.
- The patient underwent chemotherapy, leading to a complete response, and the article emphasizes enhancing awareness of ALCL's clinical presentation, diagnosis, and effective treatment options.
Article Abstract
Anaplastic large T/null cell lymphoma (ALCL) is an aggressive non-Hodgkin's lymphoma (NHL) that most commonly affects young men. Herein, we present a case of a 32-year-old male patient in severe condition with ulcerated right axillary adenopathy, diffuse subcutaneous nodules, and sepsis. He was admitted to the ED, where a bone marrow aspirate and biopsy confirmed the diagnosis of ALCL. The immunohistochemical examination demonstrated neoplastic cells with immunopositivity with antibodies CD3 (focal), CD30 (diffuse), protein ALK-1 (diffuse), and epithelial membrane antigen (EMA) (multifocal). Appropriate chemotherapy treatment was done, and the patient showed a complete response. This article aims to report a rare subtype of NHL to increase awareness and bring up a discussion about the clinical presentation and diagnostic features of ALCL. Moreover, we discuss treatment regimens that are currently used and have shown reasonable disease remission rates.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11268393 | PMC |
| http://dx.doi.org/10.7759/cureus.63040 | DOI Listing |
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