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Time-of-flight PET/CT suppresses CT based attenuation correction and scatter coincidence correction errors due to misalignment of the gastrointestinal tract. | LitMetric

AI Article Synopsis

  • This study investigated how changes in CT values impact PET images, particularly focusing on errors caused by gastrointestinal gas in CT-based attenuation correction and scatter coincidence correction (CTAC/SC).
  • The researchers compared PET pixel value fluctuations between non-time-of-flight (non-TOF) and time-of-flight (TOF) PET images, finding that TOF-PET had significantly smaller fluctuations.
  • The results indicated that TOF-PET reduces errors related to gastrointestinal gas, potentially leading to more accurate assessments in PET imaging.

Article Abstract

Objectives: This study aimed to examine the influence of changes in CT values on PET images, specifically focusing on errors in CT-based attenuation correction and scatter coincidence correction (CTAC/SC) caused by gastrointestinal gas. Furthermore, it aimed to demonstrate the effectiveness of time-of-flight (TOF) PET in reducing CTAC/SC errors.

Methods: PET images were reconstructed using multiple CT images with varying CT values. The study then compared the fluctuations in pixel values of the PET images corresponding to the different CT values utilized for CTAC/SC between non-TOF and TOF acquisitions.

Results: PET pixel values fluctuated with changes in CT values. In the phantom study, TOF showed a significantly smaller change in PET pixel value of 1.00±0.27 kBq/mL compared to 3.72±1.33 kBq/mL in the non-TOF at sites with a CT change of +1000 HU. In the patient study, a linear regression analysis was performed to determine the effect of changes in CT values due to gastrointestinal gas migration on standard uptake value (SUV).The results showed that the TOF group had a lower ratio of change in SUV to change in CT values compared to the non-TOF group. These findings revealed that PET pixel values exhibited fluctuations in response to changes in CT values, and TOF-PET effectively mitigated CTAC/SC errors arising from gastrointestinal gas.

Conclusions: TOF-PET has the potential to reduce the occurrence of suspicious accumulation.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11263777PMC
http://dx.doi.org/10.22038/AOJNMB.2024.74406.1520DOI Listing

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