AI Article Synopsis
- Cell migration plays a crucial role in the immune system, but it is not well-studied in pregnant animals, despite observed increases in spleen and lymph node sizes during pregnancy.
- In the study, researchers used a mouse model to analyze the movement of PKH26-stained immune cells from pregnant and non-pregnant mice to see how pregnancy affects cell distribution in lymphoid organs.
- Results showed that while more thymocytes were present in females compared to males, the movement of immune cells from pregnant and non-pregnant mice was similar, suggesting that larger spleen and lymph node sizes in pregnant mice may be due to leukocyte retention rather than differences in cell migration.
Article Abstract
Background: Cell migration is essential for the immune system and is frequently analyzed in adult non-pregnant animals but poorly explored in pregnant animals. However, a physiologic increased size in the spleen and periaortic lymph nodes had been reported in pregnant mice.
Methods: Using a mouse model, we transferred PKH26-stained thymocytes and splenocytes from pregnant or non-pregnant animals to receptor mice in the presence or absence of pregnancy. Percentage of PKH-26 cells and Mean Fluorescence Intensity were calculated. Non-parametric ANOVA analysis was performed.
Results: We detected that the percentage of PKH26+ thymocytes in the spleen, lymph nodes, and peripheral blood is higher in females than in males (p = 0.039). Our results showed a similar frequency of thymocytes and splenocytes from pregnant and non-pregnant mice located in receptor lymphoid organs (p > 0.05). Also, the location of marked cells was similar during the perinatal period (p > 0.05).
Conclusions: The mobility of thymocytes and splenocytes in pregnant and non-pregnant mice is similar. Therefore, we suggest that the larger size of the spleen and periaortic lymph nodes noted previously in pregnant mice could result from the retention of leukocytes in the secondary lymphoid organs.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11268130 | PMC |
| http://dx.doi.org/10.1016/j.bbrep.2024.101769 | DOI Listing |
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