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Thyroid autoimmunity is extremely common in the adult population and can affect pregnancy outcomes. Signs in the newborn can range from absent to severe, making the diagnosis easy to miss. We present an interesting case of neonatal Graves disease associated with intrauterine growth restriction, premature delivery, and liver failure with severely high ferritin, thought to be secondary to hemochromatosis. Treatment of the underlying hyperthyroidism caused a rapid resolution of the elevated ferritin and liver failure. This report highlights the importance of considering Graves disease in newborns with liver failure of unknown etiology.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11267223 | PMC |
http://dx.doi.org/10.1210/jcemcr/luae132 | DOI Listing |
Arch Dermatol Res
March 2025
Department of Dermatology, Third Xiangya Hospital, Central South University, Changsha, 410013, Hunan, China.
Previous studies have suggested a comorbidity between autoimmune thyroid disease (AITD) and urticaria. However, the causal effects between AITD and urticaria remain unclear. This study employed genome-wide association study (GWAS) data to analyze the associations between AITD and urticaria through bidirectional Mendelian randomization (MR), meanwhile, examined the role of 731 immune traits as mediators between the two diseases through mediation analysis.
View Article and Find Full Text PDFJ Affect Disord
March 2025
Department of Thyroid Surgery, General Surgery Center, The First Hospital of Jilin University, Changchun 130021, China. Electronic address:
Background: Observational studies have demonstrated associations between autoimmune thyroid disease and both mood disorders and dementia, but the direction of causality has not been established.
Methods: We employed bidirectional, two-sample Mendelian randomization analyses to assess the causal links between autoimmune thyroid disease (Graves' disease and autoimmune thyroiditis), and mood disorders (major depressive disorder and bipolar disorder) as well as dementia (Alzheimer's disease and dementia with Lewy bodies). We obtained Genome-Wide Association Study data from the Finngen database and IEU Open GWAS.
Orbit
March 2025
Department of Ophthalmology, School of Medicine de Ribeirão Preto, University of São Paulo, Ribeirao Preto, Brazil.
Purpose: To measure the amplitude of upper eyelid saccadic movements in patients with Graves' retraction.
Methods: The amplitude and velocity of lid saccades were quantified using customized software in 36 patients with Graves' upper eyelid retraction (GO) and in 32 subjects of a control group (CG). All patients were in the chronic phase of the disease and had a controlled thyroid status.
Rev Med Liege
March 2025
Service de Chirurgie viscérale, CHU-JRA, Antananarivo, Madagascar.
Introduction: the indication for pancreatic necrosectomy arises in a context of seriousness. Several factors can influence postoperative outcomes. Our objective is to identify the clinical and paraclinical factors which would influence the occurrence of complications after pancreatic necrosectomy.
View Article and Find Full Text PDFZhong Nan Da Xue Xue Bao Yi Xue Ban
October 2024
Department of Ophthalmology, Third Xiangya Hospital, Central South University, Changsha 410013, China.
Objectives: Graves' ophthalmopathy is a complex organ-specific autoimmune disease with an unclear pathogenesis. Complement component 5/5a (C5/C5a), a key element of the component system, may play a significant role in the disease's pathological process. This study aims to investigate the causal relationship between C5/C5a and Graves' ophthalmopathy using Mendelian randomization (MR) to provide new theoretical insights for its diagnosis and treatment.
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