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Strategies to decouple cell micro-scale and macro-scale environments for designing multifunctional biomimetic tissues. | LitMetric

AI Article Synopsis

  • The regulation of cellular behavior in 3D environments is a key challenge in tissue engineering, as it requires mimicking the natural organization found in native tissues.
  • Modular tissue engineering seeks to replicate this complexity by using functional building blocks that provide specific biochemical and biophysical signals to guide cellular activities.
  • Recent advancements allow for a separation of cellular microenvironments from their larger surroundings, leading to improved multifunctional and heterogeneous engineered tissues.

Article Abstract

The regulation of cellular behavior within a three-dimensional (3D) environment to execute a specific function remains a challenge in the field of tissue engineering. In native tissues, cells and matrices are arranged into 3D modular units, comprising biochemical and biophysical signals that orchestrate specific cellular activities. Modular tissue engineering aims to emulate this natural complexity through the utilization of functional building blocks with unique stimulation features. By adopting a modular approach and using well-designed biomaterials, cellular microenvironments can be effectively decoupled from their macro-scale surroundings, enabling the development of engineered tissues with enhanced multifunctionality and heterogeneity. We overview recent advancements in decoupling the cellular micro-scale niches from their macroenvironment and evaluate the implications of this strategy on cellular and tissue functionality.

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Source
http://dx.doi.org/10.1039/d4sm00276hDOI Listing

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