AI Article Synopsis
- - Trachoma is the leading cause of infectious blindness worldwide, particularly affecting indigenous Mayan populations in Chiapas, Mexico, and is linked to genetic factors that may increase the risk of developing severe cases.
- - A study involving 51 individuals with late-stage trachoma and 102 controls identified specific genetic polymorphisms (SNPs) related to inflammation, particularly in genes like BIRC3 and ABCG2, that correlate with heightened risk of the disease.
- - Key findings indicate that certain alleles, specifically the T allele of rs11807619, the C allele of rs932335, and the D allele of rs4340 in the ACE gene, are significantly associated with increased risk of late-stage tr
Article Abstract
Trachoma, caused by , is the most common infectious blindness in the world and is present in indigenous Mayan from Chiapas (Mexico). Inflammatory genes are activated when suffering from trachoma, thus some polymorphisms could increase the susceptibility to develop irreversible blindness. This study aimed to evaluate the genetic risk of developing late-stage trachoma in Mayan ethnic groups. In a case-control study ( = 51 vs = 102, respectively), the following single-nucleotide polymorphisms (SNPs) in genes related to inflammation were analysed: (rs11807619), (rs932335), ABCG2 (rs2231142), SLCO1B1 (rs4149056), IL-10 (rs1800890), TNF (rs1800629), MMP2 (rs243865) and ACE. Three SNPs were associated with late-stage trachoma risk: (i) the T allele of rs11807619, (ii) the C allele of rs932335, which are linked to the gene (OR = 22.5-27.3), particularly in men when adjusts for gender (OR = 16-16.7); and (iii) D allele of rs4340 in the ACE gene (OR = 5.2-5.3). In fact, significant linkage disequilibrium demonstrated association between ACE gene and SNPs (r = 0.17-0.179; = 0.0048-0.0073). Two SNPs gene ( = 0.013 vs 0.0039) and haplotypes showed association with late-stage trachoma in Mayan ethnic groups.
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