AI Article Synopsis
- The global incidence of hepatocellular carcinoma (HCC) is on the rise, contributing significantly to cancer-related deaths, and existing treatments remain inadequate.
- Research has advanced in understanding the molecular mechanisms of HCC, but patient survival rates are still very low.
- The review focuses on the role of ion channels and transporters in HCC development, suggesting they could serve as new targets for effective therapies.
Article Abstract
The incidence of hepatocellular carcinoma (HCC) has continued to increase annually worldwide, and HCC has become a common cause of cancer-related death. Despite great progress in understanding the molecular mechanisms underlying HCC development, the treatment of HCC remains a considerable challenge. Thus, the survival and prognosis of HCC patients remain extremely poor. In recent years, the role of ion channels in the pathogenesis of diseases has become a hot topic. In normal liver tissue, ion channels and transporters maintain water and electrolyte balance and acid‒base homeostasis. However, dysfunction of these ion channels and transporters can lead to the development and progression of HCC, and thus these ion channels and transporters are expected to become new therapeutic targets. In this review, ion channels and transporters associated with HCC are reviewed, and potential targets for new and effective therapies are proposed.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11567900 | PMC |
| http://dx.doi.org/10.1038/s41417-024-00782-8 | DOI Listing |
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