AI Article Synopsis
- - A new trinuclear rhodamine-Gd(III) complex, along with two similar mononuclear complexes, has been developed and analyzed for effectiveness.
- - These complexes show high selectivity against human glioma cells (T98G) compared to glial cells (SVG p12) and exhibit low toxicity levels.
- - The Gd(III) complexes demonstrated significantly better uptake in tumor cells at lower concentrations than other previously studied compounds, with increases in uptake of about 150% and 250%.
Article Abstract
The synthesis and characterization of a novel trinuclear rhodamine-Gd(III) complex, along with two analogous mononuclear rhodamine-Gd(III) complexes, are reported. All complexes displayed good selectivity in a human glioma cell line (T98G) when compared to a glial cell line (SVG p12), with low cytotoxicities. Superior tumor cell uptake for these Gd(III) complexes was observed at lower incubation concentrations compared to previously-reported delocalized lipophilic cations such as a rhodamine-lanthanoid(III) probe and Gd(III)-arylphosphonium complexes, with ca. 150 % and 250 % increases in Gd uptake, respectively.
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| http://dx.doi.org/10.1002/chem.202402244 | DOI Listing |
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