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Clonal dynamics after allogeneic haematopoietic cell transplantation.
Nature
November 2024
Cancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton, UK.
Article Synopsis
- Allogeneic hematopoietic cell transplantation (HCT) involves replacing a recipient's blood stem cells with those from a donor, and this study analyzed the long-term effects on stem cell populations over 9-31 years post-transplant.
- Researchers sequenced genomes from nearly 3,000 single-cell-derived blood colonies from ten donor-recipient pairs and found that younger donors contributed significantly more engrafted stem cells compared to older donors, leading to differences in blood cell types produced.
- The study identified that recipients experienced a decrease in clonal diversity, akin to accelerated aging, due to two types of selection processes: one occurring in the donor before the transplant and another in the recipient's marrow after engraftment, which revealed
Red cell distribution width as a bellwether of prognosis.
Blood Cells Mol Dis
November 2024
Department of Medicine and the James P. Wilmot Cancer Institute, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA. Electronic address:
The red cell distribution width (RDW) is a standard variable reported in the complete blood count. It has been found to have a consistent relationship to life expectancy in older individuals, prognosis in patients with cardiovascular disease, outcome in those with hematological and non-hematological neoplasms and in a variety of medical circumstances such as non-cardiovascular or cancer related critical illness and postoperative outcome from various procedures. This report reviews some of the key medical publications establishing these relationships with RDW.
View Article and Find Full Text PDFExaggerated Hematopoiesis in the First-Trimester Twin Placenta with an Unusual Morphology: A Case Report.
Ann Clin Lab Sci
May 2024
Department of Pathology and Laboratory Medicine, the Warren Alpert School of Medicine of Brown University, and Women and Infants Hospital of Rhode Island, Providence, RI, USA.
Somatic mutations related to clonal hematopoiesis of indeterminate potential (CHIP) are risk factors for stroke. The impact of , the most mutated gene in CHIP, on clinical functional outcomes of acute ischemic stroke (AIS) remains unclear. In a well-characterized cohort of 8524 ischemic stroke patients, we demonstrated that -driven CHIP was significantly associated with neurological disability in these patients.
View Article and Find Full Text PDFAn IL-10/DEL-1 axis supports granulopoiesis and survival from sepsis in early life.
Nat Commun
January 2024
Institute of Molecular Biology and Biotechnology, IMMB, FORTH, Heraklion, Greece.
Article Synopsis
- Babies have fewer neutrophils, which makes them more likely to get infections, and scientists want to understand why.
- Researchers discovered that a protein called DEL-1 is really important for helping newborn mice survive serious infections by boosting the production of neutrophils.
- When babies have a certain balance of immune proteins (IL-10 and IL-17A), it helps support DEL-1, which protects them from getting more sick during infections.
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