AI Article Synopsis
- - Allergic rhinitis (AR) is a chronic inflammation of the nasal lining triggered by allergens, leading to common symptoms like a runny nose and congestion that affect millions globally.
- - Ipratropium Bromide (IB) is a common nasal spray treatment for AR, but it requires frequent use and can irritate the nasal passage.
- - Researchers developed a novel drug delivery system that turns into a gel in the nasal cavity, allowing for sustained release of IB in response to reactive oxygen species (ROS), improving treatment effectiveness and reducing symptoms in AR models.
Article Abstract
Allergic rhinitis (AR) is a chronic inflammatory disease of the nasal mucosa mediated by immunoglobulin E (IgE) after exposure to allergens. The bothersome symptoms of AR, such as runny nose and nasal congestion, affect millions of people worldwide. Ipratropium Bromide (IB), commonly used in clinical practice for treating AR, requires frequent administration through nasal spray and may cause significant irritation to the nasal mucosa. The induction of ROS is closely related to the initiation and symptoms of AR, and ROS will continue to accumulate during the onset of AR. To address these challenges, we have designed a drug delivery system that can be administered in liquid form and rapidly crosslink into a ROS-responsive gel in the nasal cavity. This system enables sustained ROS responsive release of IB in a high-concentration ROS environment at AR lesions, thereby alleviating AR symptoms. The gel demonstrated prolonged release of IB for up to 24 hours in rats. In the treatment of AR rat models, it improved their symptoms, reduced the expression of various inflammatory factors, suppressed MUC5AC protein expression, and decreased mucus secretion through a ROS responsive IB release pattern. Overall, this system holds promise as a better option for AR treatment and may inspire the design of nanogel-based nasal drug delivery systems.
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| http://dx.doi.org/10.1016/j.colsurfb.2024.114112 | DOI Listing |
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