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Single-cell transcriptomics in thyroid eye disease.
Taiwan J Ophthalmol
October 2023
Department of Ophthalmology, Byers Eye Institute, Stanford University School of Medicine, Stanford, CA, USA.
Thyroid eye disease (TED) is a poorly understood autoimmune condition affecting the retroorbital tissue. Tissue inflammation, expansion, and fibrosis can potentially lead to debilitating sequelae such as vision loss, painful eye movement, proptosis, and eyelid retraction. Current treatment modalities for TED include systemic glucocorticoids, thioamides, methimazole, teprotumumab, beta-blockers, and radioactive iodine; however, it has been reported that up to 10%-20% of TED patients relapse after treatment withdrawal and 20%-30% are unresponsive to mainstay therapy for reasons that have yet to be more clearly elucidated.
View Article and Find Full Text PDFRabies in rural northeast India: A case report emphasising the urgency of the One Health approach.
One Health
December 2024
Jyoti and Bhupat Mehta School of Health Science and Technology, Indian Institute of Technology Guwahati, Guwahati, Assam, India.
Dog-mediated rabies is endemic in India. The country records the highest mortality due to dog-bite-related rabies despite the availability of interventions to prevent deaths. We present a case study of the death of a 59-year-old man in a suburban town of Northeast India after a dog bite from an owned pup.
View Article and Find Full Text PDFEvaluation of treadmill cardiopulmonary exercise testing and field measurement results in women's youth and adult national team water polo players.
Heliyon
January 2025
Heart and Vascular Center, Semmelweis University, Budapest, 1122, Gaal Jozsef Street 9, Hungary.
The benefits of treadmill-based cardiopulmonary exercise testing (CPET) are well known. However, water polo trainings involve completely different movements in a distinct environment. Our objective was to analyze data from elite youth and adult water polo players, gathered through CPET and age- and sport-specific swimming tests.
View Article and Find Full Text PDFMetallosis, Trunnionosis, and Head-stem Dissociation of the Exeter v40 Stem in a Metal-on-Metal Hip: A Unique Case.
J Orthop Case Rep
January 2025
Department of Trauma and Orthopaedic Surgeon, Cork University Hospital, Ireland.
Introduction: In this article, we report a unique case of head-stem dissociation in a metal-on-metal total hip replacement which utilized an Exeter stem. Although metallosis and pseudotumor formation are well recognized complications of metal-on-metal hip replacements, head-stem dissociations are rare with few being reported in literature. To the best of our knowledge, this case report is the first to report this occurrence in an Exeter stem.
View Article and Find Full Text PDFEffect of General Anesthesia Combined with Transversus Abdominis Plane Block on Postoperative Sleep Disorders in Elderly Patients Undergoing Gastrointestinal Tumor Surgery: A Prospective, Randomized Controlled Trial.
Nat Sci Sleep
January 2025
Department of Anesthesiology, Hospital for Skin Diseases (Institute of Dermatology), Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing, 210042, People's Republic of China.
Purpose: The aim of this study was to investigate the effect of general anesthesia combined with transversus abdominis plane block on postoperative sleep disorders in elderly patients undergoing gastrointestinal tumor surgery.
Methods: For elderly patients with gastrointestinal malignant tumors, we recruited 94 patients, aged 65-80, who were scheduled for radical laparoscopic surgery. Using the random number table method, the patients were randomly divided into two groups, the general anesthesia group (group GA) and the general anesthesia combined with transversus abdominis plane block group (group GT).
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