AI Article Synopsis
- - The study examines the incidence and prevalence of early-onset dementia (EOD) in two areas of Finland from 2010 to 2021, finding that the crude incidence rate was 12.3 cases per 100,000 persons per year with specific age groups showing higher rates.
- - Out of the 794 new EOD cases identified, Alzheimer’s disease (AD) was the most common subtype, making up 48.2% of cases, followed by behavioral variant frontotemporal dementia at 12.7%.
- - The findings indicate that the incidence rates for EOD are higher than previous reports, with a notable increase in early-onset AD cases over time, while other EOD subtypes remained
Article Abstract
Objectives: Current epidemiologic data of early-onset dementia (EOD), characterized by the onset of the disease before the age of 65, are notably scarce.
Methods: We evaluated the incidence (from January 2010 to December 2021) and prevalence (on December 31, 2021) of EOD and its subtypes in 2 defined areas in Finland. All visits at the dementia outpatient clinics were manually retrospectively reviewed and reassessed (N = 12,490).
Results: In the population aged ≤65 years, crude incidence of EOD was 12.3/100,000 persons at risk/year based on 794 new cases from January 1, 2010, to December 31, 2021. Incidence rates for EOD were 20.5 and 33.7 per 100,000 person years in the age group of 30-64 and 45-64 years, respectively. The prevalence of EOD was 110.4 in the age group of 30-64 years and 190.3 in the age group 45-64. Alzheimer disease (AD) (48.2%) and behavioral variant frontotemporal dementia (12.7%) were the most frequent subtypes. The incidence of AD increased during the follow-up, whereas incidence of other forms of EOD remained stable.
Discussion: We found higher incidence rates of EOD than previously reported. Unlike other forms of EOD, the incidence of early-onset AD seems to be increasing.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11314947 | PMC |
| http://dx.doi.org/10.1212/WNL.0000000000209654 | DOI Listing |
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