Phthalate esters are plasticizers that people are often exposed to in daily life. They are closely related to our lives and generally exist in the air, soil and water. Studies show that the exposure to phthalates is associated with male reproductive damage. When the concentration of phthalates reaches a certain level in the body, it can reduce the count and motility of sperm, induce abnormalities in the reproductive system and organs, and affect male fertility. This review summarizes the advances in the studies of the metabolic pathway of phthalate esters in the human body, the mechanism underlying their damage to the male reproductive system and their antagonistic effect.
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Sex- and trimester-specific impact of gestational co-exposure to organophosphate esters and phthalates on insulin action among preschoolers: Findings from the Ma'anshan birth cohort.
Environ Int
January 2025
Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, No 81 Meishan Road, Hefei 230032 Anhui, China; Key Laboratory of Population Health Across Life Cycle (Anhui Medical University), Ministry of Education of the People's Republic of China, No 81 Meishan Road, Hefei 230032,Anhui, China; Anhui Provincial Key Laboratory of Environment and Population Health across the Life Course, Anhui Medical University, No 81 Meishan Road, Hefei 230032 Anhui, China. Electronic address:
Introduction: Prenatal exposure to organophosphate esters (OPEs) and phthalic acid esters (PAEs) is ubiquitous among pregnant individuals. However, research exploring the relationship between prenatal co-exposure to OPEs and PAEs and childhood insulin function remains limited.
Methods: In this study, utilizing data from 2,246 maternal-fetal dyads in the Ma'anshan Birth Cohort, associations between co-exposure to OPEs and PAEs and insulin action were analyzed.
Exposure experiments and machine learning revealed that personal care products can significantly increase transdermal exposure of SVOCs from the environment.
J Hazard Mater
January 2025
Key Laboratory of Industrial Ecology and Environmental Engineering (MOE), School of Environmental Science and Technology, Dalian University of Technology, Dalian 116024, China.
We investigated the impacts of personal care products (PCPs) on dermal exposure to semi-volatile organic compounds (SVOCs), including phthalates, organophosphate esters, polycyclic aromatic hydrocarbons (PAHs), ultraviolet filters, and p-phenylenediamines, through an experiment from volunteers, explored the impact mechanisms of PCP ingredients on dermal exposure, and predicted the PCP effects on SVOC concentrations in human serum using machine learning. After applying PCPs, namely lotion, baby oil, sunscreen, and blemish balm, the dermal adsorption of SVOCs increased significantly by 1.63 ± 0.
View Article and Find Full Text PDFDo emerging alternatives pose similar soil ecological risks as traditional plasticizers? A multi-faceted analysis using earthworms as a case study.
J Hazard Mater
January 2025
College of Resources and Environment, Shandong Agricultural University, Tai'an, Shandong 271018, PR China. Electronic address:
The extensive application of plasticizers has led to significant environmental issues. This study focused on the ecotoxic effects on earthworms of the traditional plasticizer di(2-ethylhexyl) phthalate (DEHP) and non-phthalate plasticizers di(ethylhexyl) terephthalate (DEHT) and acetyltributyl citrate (ATBC). At an environmentally relevant concentration (50 mg/kg), significant accumulation of ROS was observed in earthworms, with a trend of DEHP > DEHT > ATBC, inducing oxidative stress and lipid peroxidation.
View Article and Find Full Text PDF[Analysis of phthalate esters and their novel alternatives in indoor dust using comprehensive two-dimensional gas chromatography-time of flight mass spectrometry].
Se Pu
February 2025
Key Laboratory of Beijing on Regional Air Pollution Control, Beijing University of Technology, Beijing 100214, China.
A comprehensive two-dimensional gas chromatography-time-of-flight mass spectrometry (GC×GC-TOF-MS) method was developed to analyze 25 traditional phthalate esters (PAEs) and 19 novel alternatives in indoor dust samples. PAEs are ubiquitous in indoor environments because they are widely used as plasticizers in a variety of consumer products, and potential health concerns have prompted the need for effective monitoring methods. In this study, dust samples were collected from various indoor settings in a university campus, including classrooms, cafeterias, laboratories, and dormitories, and were subsequently ultrasonically extracted with hexane-dichloromethane (1∶1, v/v) solution for 30 min.
View Article and Find Full Text PDFPhthalate exposure induces microRNA-5010/Nrf2-EGR1/GDF15 signaling expression in prostate cancer.
Ecotoxicol Environ Saf
January 2025
Department of Urology, An-Nan Hospital, China Medical University, Tainan, Taiwan. Electronic address:
Phthalate exposure is linked to prostate enlargement through sex hormonal changes and oxidative stress. However, its role and action mechanism in prostate cancer remain unclear. This study examined two patient cohorts: 204 patients undergoing prostate biopsy (24 benign and 180 malignancies) and 85 with confirmed prostate cancer receiving robotic-assisted radical prostatectomy.
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