Glycosylation with sulfoxide-based glycosyl donors.

Chem Commun (Camb)

School of Pharmacy, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, China.

Published: August 2024

AI Article Synopsis

  • Sulfoxides play a crucial role in carbohydrate chemistry, particularly as anomeric leaving groups in glycosylation reactions.
  • The article highlights recent advancements and developments in the use of glycosyl sulfoxide donors.
  • It aims to address challenges and future opportunities in this area of research, fostering better understanding and progress in carbohydrate chemistry.

Article Abstract

Sulfoxides have emerged as pivotal constituents in modern carbohydrate chemistry. As anomeric leaving groups, sulfinyl moieties may occupy positions directly at the anomeric position or at a more remote site. This feature article is focused on the evolution and notable advancements of glycosyl sulfoxide donors in glycosylation reactions. Its objective is to elucidate the obstacles and prospects within this evolving research domain, with the aim of enhancing comprehension and progress in the field of carbohydrate chemistry.

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Source
http://dx.doi.org/10.1039/d4cc02838dDOI Listing

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