An efficient palladium-catalyzed cascade cyclization/carbonylation of indoles with aryl formates to access ester-functionalized indolo[2,1-]isoquinoline scaffolds has been developed. In addition, an asymmetric variant is also achieved using a chiral phosphine ligand, affording the indolo[2,1-]isoquinoline products in good yields and enantioselectivities.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1039/d4cc02577f | DOI Listing |
Publication Analysis
Top Keywords
cyclization/carbonylation indoles
8
indoles aryl
8
aryl formates
8
pd-catalyzed cascade
4
cascade heck
4
heck cyclization/carbonylation
4
formates enantioselective
4
enantioselective construction
4
construction indolo[21-]isoquinolines
4
indolo[21-]isoquinolines efficient
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!