AI Article Synopsis
- The aim of the study was to create a reliable animal model for non-occlusive mesenteric ischemia (NOMI) to understand its pathophysiology better, as current treatments are not well-established.
- Researchers conducted experiments in pigs using different combinations of hemorrhagic shock and vasopressor infusions to simulate NOMI conditions and assess their effects.
- The study successfully developed a model that showed significant intestinal changes and elevated serum lactate levels when systemic norepinephrine was combined with local epinephrine after moderate blood loss, confirming the effectiveness of this approach for studying NOMI.
Article Abstract
Aim: Non-occlusive mesenteric ischemia (NOMI) is associated with high mortality rates, but definitive treatments have not yet been established. Although experimental animal models are worthwhile, reproducible models that reflect the pathophysiology of NOMI have not been developed.
Methods: We combined risk factors for NOMI, comprising hemorrhagic shock, systemic vasopressor infusion, and local vasopressor infusion from the superior mesenteric artery (SMA) in swine under maintained anesthesia. Experiment 1 involved full-intensity (40%) phlebotomy and systemic vasopressor (norepinephrine and epinephrine). Experiment 2 involved full-intensity (40%) phlebotomy, systemic norepinephrine, and local vasopressor infusion into the SMA. Experiment 3 involved moderate (27%) phlebotomy, systemic norepinephrine infusion, and local epinephrine infusion. We evaluated serum lactate levels, intestinal serosa color, computed tomography (CT) angiography, and pathological findings.
Results: After inducing hemorrhage, systemic vasopressor alone and in combination with local vasopressin or norepinephrine infusion did not induce ischemic color changes in the intestine. The combination of systemic norepinephrine and local epinephrine (0.5 μg/kg/min) after moderate (27% blood loss) hemorrhage induced gross color change, pathological destruction, and elevation of serum lactate. Patent flow in the SMA was confirmed on CT angiography.
Conclusion: We established a swine NOMI model with systemic norepinephrine infusion and local epinephrine with moderate hemorrhagic shock.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11263749 | PMC |
| http://dx.doi.org/10.1002/ams2.982 | DOI Listing |
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