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[F]RCCB6 Immuno-Positron Emission Tomography/Computed Tomography for Postoperative Surveillance in Clear Cell Renal Cell Carcinoma: A Pilot Clinical Study.
Eur Urol
October 2024
Department of Urology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. Electronic address:
ImmunoPET/CT imaging of clear cell renal cell carcinoma with [F]RCCB6: a first-in-human study.
Eur J Nucl Med Mol Imaging
July 2024
Department of Nuclear Medicine, Institute of Clinical Nuclear Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, 1630 Dongfang Rd, Shanghai, 200127, China.
Purpose: The cluster of differentiation (CD70) is a potential biomarker of clear cell renal cell carcinoma (ccRCC). This study aims to develop CD70-targeted immuno-positron emission tomography/computed tomography (immunoPET/CT) imaging tracers and explore the diagnostic value in preclinical studies and the potential value in detecting metastases in ccRCC patients.
Methods: Four novel CD70-specific single-domain antibodies (sdAbs) were produced and labelled with F by the aluminium fluoride restrained complexing agent (AlF-RESCA) method to develop radiotracers.
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