AI Article Synopsis
- - Histoplasmosis is a serious fungal infection linked to high death rates in people with advanced HIV, prompting this study to assess its global prevalence of antigenuria in HIV-positive individuals.
- - The research included 15 studies after screening nearly 1,300, revealing that 11% of individuals with HIV and 13% of those with advanced HIV had detectable Histoplasma antigens in their urine.
- - The findings suggest that those with advanced HIV, especially symptomatic patients and hospitalized individuals, could greatly benefit from routine urine antigen tests for early histoplasmosis detection.
Article Abstract
Histoplasmosis is a fungal disease associated with substantial mortality rates among persons with advanced HIV disease. Our systematic review synthesized data on the global prevalence of Histoplasma--caused antigenuria in persons with HIV. We searched PubMed/Medline, Embase, and Scopus databases on January 3, 2023, to identify cross-sectional and cohort studies evaluating Histoplasma antigenuria prevalence among adults with HIV infection. We calculated point estimates and 95% CIs to summarize prevalence. Of 1,294 studies screened, we included 15. We found Histoplasma antigenuria among 581/5,096 (11%; 95% CI 11%-12%) persons with HIV and 483/3,789 persons with advanced HIV disease (13%; 95% CI 12%-14%). Among persons with HIV and symptoms consistent with histoplasmosis, Histoplasma antigenuria prevalence was 14% (95% CI 13%-15%; 502/3,631 participants). We determined that persons with advanced HIV disease, inpatients, and symptomatic persons might benefit from a systematic approach to early detection of histoplasmosis using urine antigen testing.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11286068 | PMC |
| http://dx.doi.org/10.3201/eid3008.231710 | DOI Listing |
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