AI Article Synopsis
- Human infections from Corynebacterium diphtheriae species complex (CdSC) in French Guiana increased significantly from 2016 to 2021, with 64 infections reported in 60 patients during this time period.
- The incidence of CdSC infections rose from 0.7 cases per 100,000 in 2016 to 7.7 cases per 100,000 in 2021, with the majority of cases being cutaneous.
- Most patients were around 30 years old, and the majority of infections were caused by C. diphtheriae, highlighting the need for greater awareness among healthcare providers for better prevention and management.
Article Abstract
Human infections with Corynebacterium diphtheriae species complex (CdSC) bacteria were rare in French Guiana until 2016, when the number of cases diagnosed increased. We conducted an epidemiologic, multicenter, retrospective study of all human CdSC infections diagnosed in French Guiana during January 1, 2016-December 31, 2021. A total of 64 infectious episodes were observed in 60 patients; 61 infections were caused by C. diphtheriae and 3 by C. ulcerans. Estimated incidence increased from 0.7 cases/100,000 population in 2016 to 7.7 cases/100,000 population in 2021. The mean patient age was 30.4 (+23.7) years, and male-to-female ratio was 1.7:1 (38/22). Of the 61 C. diphtheriae isolates, 5 tested positive for the diphtheria toxin gene, and all results were negative by Elek test; 95% (61/64) of cases were cutaneous, including the C. ulcerans cases. The increase in reported human infections underscores the need to raise awareness among frontline healthcare practitioners to improve prevention.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11286053 | PMC |
| http://dx.doi.org/10.3201/eid3008.231671 | DOI Listing |
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