While Bayesian methodology is increasingly favored in behavioral research for its clear probabilistic inference and model structure, its widespread acceptance as a standard meta-analysis approach remains limited. Although some conventional Bayesian hierarchical models are frequently used for analysis, their performance has not been thoroughly examined. This study evaluates two commonly used Bayesian models for meta-analysis of standardized mean difference and identifies significant issues with these models. In response, we introduce a new Bayesian model equipped with novel features that address existing model concerns and a broader limitation of the current Bayesian meta-analysis. Furthermore, we introduce a simple computational approach to construct simultaneous credible intervals for the summary effect and between-study heterogeneity, based on their joint posterior samples. This fully captures the joint uncertainty in these parameters, a task that is challenging or impractical with frequentist models. Through simulation studies rooted in a joint Bayesian/frequentist paradigm, we compare our model's performance against existing ones under conditions that mirror realistic research scenarios. The results reveal that our new model outperforms others and shows enhanced statistical properties. We also demonstrate the practicality of our models using real-world examples, highlighting how our approach strengthens the robustness of inferences regarding the summary effect.
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http://dx.doi.org/10.1080/00273171.2024.2358233 | DOI Listing |
Clin Infect Dis
January 2025
EPIUnit - Instituto de Saúde Pública, Universidade do Porto, Porto, Portugal.
Background: Higher than standard doses of rifampicin could improve the treatment outcome of drug-susceptible tuberculosis without compromising the safety of patients.
Methods: We performed a systematic review of prospective clinical studies including adults with pulmonary and extrapulmonary TB receiving rifampicin doses above 10mg/kg/day. We extracted the data on overall adverse events (AE), hepatic AE, sputum culture conversion (SCC) at week 8, recurrence, mortality, and pharmacokinetics.
Antimicrob Agents Chemother
January 2025
InsightRX, San Francisco, California, USA.
Tobramycin dosing in patients with cystic fibrosis (CF) is challenged by its high pharmacokinetic (PK) variability and narrow therapeutic window. Doses are typically individualized using two-sample log-linear regression (LLR) to quantify the area under the concentration-time curve (AUC). Bayesian model-informed precision dosing (MIPD) may allow dose individualization with fewer samples; however, the relative performance of these methods is unknown.
View Article and Find Full Text PDFMethodsX
June 2025
Department of Statistics, Institut Teknologi Sepuluh Nopember, Surabaya 60111 Indonesia.
This research introduces the Generalized Extreme Value Mixture Autoregressive (GEVMAR) model as an innovative approach for examining non-standard actuarial datasets within general insurance. Information concerning claim reserves often reveals notable volatility and multimodal distributions, attributes that standard models, including previous method such as the Gaussian Mixture Autoregressive (GMAR) model and other autoregressive methodologies, find problematic to manage effectively. The GEVMAR model integrates the Generalized Extreme Value (GEV) distribution alongside Bayesian estimation techniques, augmented by a modified Signal-to-Noise Ratio (SNR) metric to improve predictive accuracy.
View Article and Find Full Text PDFBr J Pain
January 2025
Department of Psychology, University of Warwick, Coventry, UK.
Objectives: Validate the English version of the (SCS-SF) as a reliable measure in chronic pain. Explore self-compassion's relationship with pain-related outcomes.
Methods: A total of 240 chronic pain patients (at 6-months) and 256 community participants (at 12-months) completed two prospective survey studies.
PNAS Nexus
January 2025
Department of Mathematics, Aston University, Birmingham B4 7ET, United Kingdom.
Understanding the relation between cortical neuronal network structure and neuronal activity is a fundamental unresolved question in neuroscience, with implications to our understanding of the mechanism by which neuronal networks evolve over time, spontaneously or under stimulation. It requires a method for inferring the structure and composition of a network from neuronal activities. Tracking the evolution of networks and their changing functionality will provide invaluable insight into the occurrence of plasticity and the underlying learning process.
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