Background: Gastric cancer (GC), a malignant epithelial tumor, is the fourth leading cause of cancer-related death worldwide. Therapeutic strategies for GC, despite the biggest challenges, can significantly improve survival rates through early detection and effective screening methods.
Aim: To provide brief information on the necessity of multiple specific diagnostic, prognostic, and predictive markers for GC.
Methods: This review was conducted using a variety of search engines, including PubMed Central, Scopus, Web of Science, Google Scholar, and others.
Results: Some potential biomarkers that provide essential information include circulating tumor cells (CTCs), DNA methylation, claudin 18.2, fibroblast growth factor receptor 2 (FGFR2), long noncoding RNAs (lncRNAs), cell-free DNA (cfDNA), microRNAs, and serum pepsinogens.
Conclusion: Multiple tumor markers are essential for screening, tumor identification, staging, prognostic assessment, and monitoring recurrence after therapy due to the absence of a single tumor indicator for diagnosing, prognosticating, and predicting GC.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11260885 | PMC |
| http://dx.doi.org/10.1002/hsr2.2261 | DOI Listing |
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