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| http://dx.doi.org/10.1016/j.nmni.2024.101448 | DOI Listing |
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Structural analyses of Cryptosporidium parvum epitopes reveal a novel scheme of decapeptide binding to H-2K.
J Struct Biol
January 2025
State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, PR China. Electronic address:
Cryptosporidium has gained much attention as a major cause of diarrhea worldwide. Here, we present the first structure of H-2K complexed with a decapeptide from Cryptosporidium parvum Gp40/15 protein (Gp40/15-VTF10). In contrast to all published structures, the aromatic residue P3-Phe of Gp40/15-VTF10 is anchored in pocket C rather than the canonical Y/F at P5 or P6 reported for octapeptides and nonapeptides.
View Article and Find Full Text PDFStructure guided modification of 2-chloro-5-(ethyl-phenyl-sulfamoyl)-N-[2-(2-oxo-pyrrolidin-1-yl)-phenyl]-benzamide to afford selective inhibitors of Cryptosporidium parvum N-myristoyltransferase.
Bioorg Med Chem Lett
January 2025
Department of Biochemistry, University of Washington, Seattle, WA 98195, United States. Electronic address:
Cryptosporidium parvum is a protozoan parasite that causes severe diarrheal illness in children and each year nearly 50,000 children under age 5 die due to the disease. Despite tremendous research efforts, there remains a lack of effective therapies and vaccines. Novel inhibitors against N-myristoyltransferase of C.
View Article and Find Full Text PDFEntamoeba histolytica and Cryptosporidium co-infections in an HIV-infected, viral suppressed patient with a normal CD4 count.
J Microbiol Immunol Infect
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Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Department of Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan. Electronic address:
The effects of rain and drought on incidence of enteric disease in Pennsylvania (2010-2019).
Environ Res
December 2024
Department of Epidemiology and Biostatistics, Temple University Philadelphia, PA, USA; Water, Health and Applied Microbiology Lab, Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, ON, Canada. Electronic address:
Background: Campylobacter, nontyphoidal Salmonella, Cryptosporidium, and Giardia cause an estimated 1 million cases of domestically acquired waterborne diseases annually in the United States. Acute symptoms can include diarrhea and vomiting; however, these illnesses can result in longer term complications such as reactive arthritis, Guillan Barré syndrome and death, particularly in immunocompromised individuals. Precipitation and drought can plausibly increase the risk of enteric infections, but consensus in the literature is lacking.
View Article and Find Full Text PDFHuman milk improves the oral bioavailability of the poorly water-soluble drug clofazimine.
Eur J Pharm Biopharm
December 2024
Drug Delivery Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University (Parkville Campus), 381 Royal Parade, Parkville, VIC 3052, Australia; Department of Pharmacy, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark. Electronic address:
Clofazimine is an emerging drug for the treatment of cryptosporidiosis in infants. As a poorly water-soluble drug, the formulation of clofazimine in age-appropriate vehicles is challenging and often results in the use of off-label formulations. Milk-based vehicles such as human milk and bovine milk have been investigated as age-appropriate formulations and shown to increase the solubilisation of poorly water-soluble drugs via enhanced solubility in lipid digestion products in vitro.
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