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Reply to correspondence regarding "UBE2S: A novel driver of HIF-1alpha-induced metabolic reprogramming in hepatocellular carcinoma.
Clin Mol Hepatol
August 2024
Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University.
UBE2S facilitates glioblastoma progression through activation of the NF-κB pathway via attenuating K11-linked ubiquitination of AKIP1.
Int J Biol Macromol
October 2024
Department of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, Harbin, China. Electronic address:
Background: Rapid proliferation is a hallmark of glioblastoma multiforme (GBM) and a major contributor to its recurrence. Aberrant ubiquitination has been implicated in various diseases, including cancer. In our preliminary studies, we identified Ubiquitin-conjugating enzyme E2S (UBE2S) as a potential glioma biomarker, exhibiting close associations with glioma grade and protein phosphatase 1, regulatory subunit 105 (Ki67) expression levels.
View Article and Find Full Text PDFUBE2S: A novel driver of HIF-1alpha-induced metabolic reprogramming in hepatocellular carcinoma.
Clin Mol Hepatol
July 2024
Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University.
Prognostic and Immune Landscape Analysis of Ubiquitination-related Genes in Hepatocellular Carcinoma: Based on Bulk and Single-cell RNA Sequencing Data.
J Cancer
March 2024
The Key Laboratory of Tumor Molecular Diagnosis and Individualized Medicine of Zhejiang Province, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, 310000, China.
Despite significant advances in tumor immunotherapy, hepatocellular carcinoma (HCC) remains a malignancy with a challenging prognosis. The increasing research emphasizes the crucial role of ubiquitination in tumor immunotherapy. However, the establishment of prognostic signatures based on ubiquitination-related genes (UbRGs) and their role in immunotherapy are still lacking in HCC.
View Article and Find Full Text PDFDiverse roles of UBE2S in cancer and therapy resistance: Biological functions and mechanisms.
Heliyon
January 2024
Department of Gynecology, The Third Affiliated Hospital of Zhengzhou University, 7 Rehabilitation Front Street, Zhengzhou 450052, China.
The Ubiquitin Conjugating Enzyme E2 S (UBE2S), was initially identified as a crucial member in controlling substrate ubiquitination during the late promotion of the complex's function. In recent years, UBE2S has emerged as a significant epigenetic modification in various diseases, including myocardial ischemia, viral hepatitis, and notably, cancer. Mounting evidence suggests that UBE2S plays a pivotal role in several human malignancies including breast cancer, lung cancer, hepatocellular carcinoma and etc.
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