A cyclic diamine, 1-methyl-4-(trifluoromethylthio)piperazine (MTTP, ), prepared by a one-step reaction from commercial materials, is a shelf-stable and powerful electrophilic trifluoromethylthiolating (CFS) reagent with wide reactivity profile. Activation of with triflic acid (TfOH) yields two reactive species and , depending on the molar ratios of TfOH/. showed unprecedented high reactivity, making possible the trifluoromethylthiolation of electron-deficient aromatic systems. In addition, accomplished the trifluoromethylthiolation of active methylene compounds under acidic conditions.
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Sijunzi San alleviates the negative energy balance in postpartum dairy cows by regulating rumen fermentation capacity.
Front Vet Sci
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College of Animal Science and Technology, Ningxia University, Yinchuan, China.
Introduction: Postpartum dairy cows are susceptible to negative energy balance caused by decreased feed intake and the initiation of lactation. Sijunzi San, a famous Chinese traditional herbal formulation, can promote gastrointestinal digestion and absorption and improve disorders of intestinal microbiota. Therefore, we hypothesized that Sijunzi San might alleviate negative energy balance in postpartum dairy cows by modulating the structure of the rumen microbiota and enhancing its fermentation capacity.
View Article and Find Full Text PDFA novel mutation, Ile344Asn, in microsomal triglyceride transfer protein abolishes binding to protein disulfide isomerase.
J Lipid Res
December 2024
Department of Foundations of Medicine, NYU Grossman Long Island School of Medicine, Mineola, NY, USA. Electronic address:
Microsomal triglyceride transfer protein (MTP) plays crucial roles in the assembly and secretion of apolipoprotein B-containing lipoproteins and loss of function MTP variants are associated with abetalipoproteinemia, a disease characterized by the absence of these lipoproteins. MTP is a heterodimeric protein of two subunits, MTP and protein disulfide isomerase (PDI). In this study, we report a proband with abetalipoproteinemia who was monitored annually for 10 years in her third decade and had very low plasma lipids and undetectable apoB-containing lipoproteins.
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Front Nutr
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College of Animal Science and Technology, Northwest A&F University, Yangling, China.
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View Article and Find Full Text PDFThe intestine-specific homeobox (ISX) modulates β-carotene-dependent regulation of microsomal triglyceride transfer protein (MTP) in a tissue-specific manner.
Biochim Biophys Acta Mol Cell Biol Lipids
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Department of Food Science, Rutgers Center for Lipid Research, Institute of Food Nutrition and Health, Rutgers University, New Brunswick, NJ, USA. Electronic address:
Vitamin A is an essential nutrient crucial to ensuring proper mammalian embryonic development. β-Carotene is the most prevalent form of vitamin A in food that, when transferred in its intact form from mother to the developing tissues, can serve as an in situ source of retinoic acid, the active form of vitamin A. We have previously provided evidence that the maternal-fetal transfer of β-carotene across the placenta is mediated by lipoproteins and that β-carotene itself regulates placenta lipoprotein biogenesis by means of its derivatives β-apo-10'-carotenoids and retinoic acid.
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