AI Article Synopsis
- Researchers are developing a drug delivery system (DDS) tailored for the gastrointestinal system to increase drug effectiveness and reduce side effects.
- The traditional challenges in the GI tract, such as fast-moving digestive juices and muscle contractions, can quickly eliminate drug carriers.
- The study introduces a boric hydroxyl-modified mesoporous Mg(OH) carrier that forms a viscous gel to improve drug retention and biocompatibility in the GI environment.
Article Abstract
Developing a microenvironment-responsive drug delivery system (DDS) for the gastrointestinal system is of great interest to enhance drug efficiency and minimize side effects. Unfortunately, the rapid-flowing digestive juice in the gastrointestinal tract and the continuous contraction and peristalsis of the gastrointestinal tract muscle accelerate the elimination of drug carriers. In this study, a boric hydroxyl-modified mesoporous Mg(OH) drug carrier is prepared to prolong the drug retention time. Results show that the newly designed DDS presents high biocompatibility and can immediately turn the free polyhydric alcohol molecules into a gelation form. The in situ-formed gelation network presents high viscosity and can prevent the drug carriers from being washed away by the digestive juice in the gastrointestinal tract.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/acsbiomaterials.4c00751 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!