AI Article Synopsis
- Surface modification can improve how effectively nanovehicles deliver genes or drugs to cells, but it's not clear how different surface parameters affect this process.
- The study focuses on a specific DNA structure shaped like an icosahedron and tests three types of ligands with varying properties to see how they impact cell entry and processing by the cell.
- By comparing these different modifications, the research provides valuable insights into how to design more effective DNA nanostructures for targeted delivery in therapeutic applications.
Article Abstract
Surface modification could enhance the cell internalization efficiency of nanovehicles for targeted gene or drug delivery. However, the influence of surface modification parameters, including recognition manners, valences, and patterns, is often clouded, especially for the endocytosis of DNA nanostructures in customized shapes. Focusing on an icosahedral DNA framework, we systematically programmed three distinct types of ligands with diverse valence and spatial distribution on their outer surface to study the internalization efficiency, endocytic pathways, and postinternalization fate. The comparison in different aspects of parameters deepens our understanding of the intricate relationship between surface modification and cell entry behavior, offering insights crucial for designing and optimizing DNA framework nanostructures for potent cell-targeted purposes.
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| http://dx.doi.org/10.1021/jacs.4c04106 | DOI Listing |
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