AI Article Synopsis
- * Researchers investigated somatostatin receptor (SSTR) expression in cardiac samples from patients with end-stage ischemic cardiomyopathy (ICM) and controls, finding decreased SSTR5 and increased SSTR1 and SSTR2 in the ICM samples.
- * The findings suggest SSTR can be upregulated in cardiac fibrotic areas, indicating that when using 68Ga-DOTATATE PET imaging for detecting cardiac conditions, unusual tracer uptake in these fibrotic areas
Article Abstract
A patient with a neuroendocrine tumor and history of coronary artery disease underwent PET with 68Ga-DOTATATE PET tracer for tumor visualization. Analysis of the scan showed uptake of 68Ga-DOTATATE in the left ventricle corresponding to previous myocardial infarct. 68Ga-DOTATATE binds by somatostatin receptors (SSTR) and it has been proposed that it may be useful for the detection of cardiac inflammatory lesions. We aimed to test whether SSTR could be upregulated in cardiac fibrotic scar. We analyzed SSTR in cardiac samples from patients with end-stage ischemic cardiomyopathy (ICM, n = 8) and control hearts (n = 5). In mature ICM tissue, SSTR1 and SSTR2 expression was unchanged and SSTR5 expression was significantly decreased in ICM samples vs. control. Immunohistochemistry showed increased SSTR1 and SSTR2 in ICM. Areas with SSTR1 or SSTR2 staining were often adjacent to fibrotic areas. The majority of SSTR1 and SSTR2 staining localized in cardiomyocytes in fibrotic scar-rich areas where CD68 macrophage staining was not present. SSTR are occasionally upregulated in cardiac fibrotic areas. When using 68Ga-DOTATATE PET tracer to detect cardiac sarcoidosis or atherosclerotic plaque, the possibility of tracer uptake in fibrotic areas should be considered.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11262693 | PMC |
| http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0304813 | PLOS |
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