Nickel-catalyzed aqueous cyanation of allylic alcohols is herein described. This catalytic protocol provided environmentally friendly and operationally simple access to a variety of allylic nitriles in good yields. For chiral allylic alcohols, the reaction gave chiral allylic nitriles with a high degree of chiral inversion. The accelerated release of cyanide in HO was crucial for the success of this reaction.
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| http://dx.doi.org/10.1021/acs.orglett.4c02211 | DOI Listing |
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