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C Tracer Analysis and Metabolomics in Dormant Cancer Cells. | LitMetric

C Tracer Analysis and Metabolomics in Dormant Cancer Cells.

Methods Mol Biol

Department of Genomic Medicine, GENYO, Centre for Genomics and Oncology, Pfizer-University of Granada and Andalusian Regional Government, PTS, Granada, Spain.

Published: July 2024

AI Article Synopsis

Article Abstract

Over the last two decades, major advances in the field of tumor dormancy have been made. Yet, it is not completely understood how dormant disseminated tumor cells survive and transition to a proliferative state to generate a metastatic lesion. On the other hand, metabolic rewiring has been shown to influence metastasis development through the modulation of both intracellular signaling and the crosstalk between metastatic cells and their microenvironment. Thus, studying the metabolic features of dormant disseminated tumor cells has gained importance in understanding the dormancy process. Here, we describe a method to perform metabolomics and C tracer analysis in 3D cultures of dormant breast cancer cells.

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Source
http://dx.doi.org/10.1007/978-1-0716-3882-8_15DOI Listing

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