AI Article Synopsis
- Deep-seated fungal infections often require prolonged antifungal treatments due to resistance issues.
- The article by Ponta et al. explores the use of rezafungin, a new long-acting antifungal, for extended therapy.
- The findings suggest that rezafungin could be a viable option for long-term treatment of infections resistant to standard antifungal medications.
Article Abstract
Deep-seated spp. infections may necessitate extended durations of antifungal therapy. Increasing resistance to first-line antifungals threatens the most common options for long-term treatment. In this issue, Ponta et al. (Antimicrob Agents Chemother 68:e00750-24, 2024, https://doi.org/10.1128/aac.00750-24) present cases in which they used rezafungin, a novel long-acting echinocandin antifungal, for extended durations. While excellent clinical evidence supports the short-term safety of rezafungin, these cases demonstrate that rezafungin may additionally have a role in long-term suppressive therapy for antifungal-resistant spp. infections.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11304684 | PMC |
| http://dx.doi.org/10.1128/aac.00847-24 | DOI Listing |
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