Background: Sepsis is a severe and potentially life-threatening condition characterized by a dysregulated host response and organ dysfunction. The causal relationship between intestinal microbiota and sepsis is unclear.
Methods: A two-sample Mendelian randomization (MR) study was performed to proxy the causal association between gut microbiota and sepsis. The genome-wide association study (GWAS) data of sepsis and gut microbiome were collected from the Integrative Epidemiology Unit (IEU) OpenGWAS, with summary-level data obtained from the UK Biobank. Five traditional methods were used to estimate the potential causal relationships between gut microbiota and sepsis, including the inverse-variance weighted method, weighted median method, MR-Egger regression, simple mode, and weighted mode. Reverse MR analysis was performed on the bacteria that were found to be causally associated with sepsis in forward MR analysis. Cochran's statistic was used to quantify the heterogeneity of instrumental variables.
Results: The inverse-variance weighted estimate suggested that class Lentisphaeria (odds ratio [OR]=0.86, 95% confidence interval [CI]: 0.78 to 0.94, =0.0017, =0.1596) and order Victivallales (OR=0.86, 95% CI: 0.78 to 0.94, =0.0017, =0.1596) have a protective effect on sepsis. The genus group (OR=1.34, 95% CI: 1.11 to 1.63, =0.0029, =0.1881) was positively associated with the risk of sepsis. Sepsis may be a significant risk factor for genus (OR=1.18, 95% CI: 1.10 to 1.39, =0.0415, =0.9849) and (OR=1.21, 95% CI: 1.00 to 1.46, =0.0471, =0.9849), but this effect was not statistically significant after false discovery rate correction. There was a suggestive association between sepsis and (OR=0.85, 95% CI: 0.73 to 0.98, =0.0278) and 1 (OR=0.85, 95% CI: 0.73 to 1.00, =0.0439), which were not significant after false discovery rate correction (>0.2).
Conclusions: This study found that class Lentisphaeria, order Victivallales, and genus group may have a causal relationship with the risk of sepsis.
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| http://dx.doi.org/10.1016/j.jointm.2023.11.006 | DOI Listing |
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