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| http://dx.doi.org/10.1016/j.jds.2024.05.010 | DOI Listing |
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Machine learning-based prognostic model of lactylation-related genes for predicting prognosis and immune infiltration in patients with lung adenocarcinoma.
Cancer Cell Int
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Yangzhou Clinical Medical College, Dalian Medical University, Yangzhou, 225001, China.
Background: Histone lactylation is a novel epigenetic modification that is involved in a variety of critical biological regulations. However, the role of lactylation-related genes in lung adenocarcinoma has yet to be investigated.
Methods: RNA-seq data and clinical information of LUAD were downloaded from TCGA and GEO datasets.
Sotorasib inhibits ubiquitination degradation of TXNIP and suppresses glucose metabolism in mutant bladder cancer.
Am J Cancer Res
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Department of Oncology, Hunan Provincial People's Hospital, The First Affiliated Hospital of Hunan Normal University Changsha, Hunan, China.
Bladder cancer is the most common malignant tumor of the urinary system. Currently, treatment strategies for bladder cancer remain limited, highlighting the urgent need to explore novel therapeutic approaches. Sotorasib, the first successful small molecule drug targeting KRAS, has been approved for treating non-small cell lung cancer (NSCLC), but it has not yet been studied in bladder cancer.
View Article and Find Full Text PDFMRTX1133 attenuates KRAS mutated-colorectal cancer progression through activating ferroptosis activity via METTL14/LINC02159/FOXC2 axis.
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Department of Gastrointestinal Surgery, The Second Affiliated Hospital of Wannan Medical College, Wuhu, Anhui, China. Electronic address:
Colorectal cancer (CRC) ranks as the third most commonly diagnosed cancer and the second leading cause of cancer-related deaths worldwide. Studies have shown that CRC patients with KRAS mutations, especially KRAS, have an increased risk of metastasis. Emerging evidence indicates that long non-coding RNAs (lncRNAs) are crucial in the carcinogenesis and progression of various cancers, regulating multiple biological processes but the link between KRAS mutations and lncRNAs in CRC remains unclear.
View Article and Find Full Text PDFCancer cachexia (CC), a syndrome of skeletal muscle and adipose tissue wasting, reduces responsiveness to therapies and increases mortality. There are no approved treatments for CC, which may relate to discordance between pre-clinical models and human CC. To address the need for clinically relevant models, we generated tamoxifen-inducible, epithelial cell specific ( ) mice.
View Article and Find Full Text PDFExploring somatic mutations in , , and as therapeutic targets in Saudi colorectal cancer patients through massive parallel sequencing and variant classification.
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Department of Clinical Biochemistry, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.
Background: Colorectal cancer (CRC) is the leading cancer among Saudis, and mutations in , , and genes are therapeutically significant due to their association with pathways critical for cell cycle regulation. This study evaluates the prevalence and frequency of somatic mutations in these actionable genes in Saudi CRC patients and assesses their pathogenicity with bioinformatics methods.
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