A conjugated polymer, P4TTD-DPP, based on tetra-fused isoindigo--diketopyrrolopyrrole, has been synthesized as a photothermal therapeutic nanotransducer within the near-infrared-II (NIR-II) window. P4TTD-DPP exhibits a notable mass extinction coefficient of 62.8 L g cm at 1064 nm. Additionally, P4TTD-DPP nanoparticles demonstrate remarkable photothermal conversion efficiency of 91.5% at 1064 nm and exhibit excellent anticancer efficacy under photothermal conditions.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1039/d4cc02546f | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Ferroelectric Nematic Liquid Crystals Showing High Birefringence.
Adv Sci (Weinh)
January 2025
South China Advanced Institute for Soft Matter Science and Technology, School of Emergent Soft Matter, South China University of Technology, Guangzhou, 510640, China.
High birefringence nematic liquid crystals are particularly demanded for adaptive optics applications in the infrared spectrum because it enable a thinner cell gap for achieving fast response time and improved diffraction efficiency. The emerging ferroelectric nematic liquid crystals have attracted widespread interest in soft matter due to their unique combination of ferroelectricity and fluidity. However, the birefringence, which is one of the most important optical parameters in electro-optic devices, is not large enough (<0.
View Article and Find Full Text PDFA Subtype Specific Probe for Targeted Magnetic Resonance Imaging of M2 Tumor-Associated Macrophages in Brain Tumors.
Acta Biomater
January 2025
Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, United States of America; Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia 30322, United States of America. Electronic address:
Pro-tumoral M2 tumor-associated macrophages (TAMs) play a critical role in the tumor immune microenvironment (TIME), making them an important therapeutic target for cancer treatment. Approaches for imaging and monitoring M2 TAMs, as well as tracking their changes in response to tumor progression or treatment are highly sought-after but remain underdeveloped. Here, we report an M2-targeted magnetic resonance imaging (MRI) probe based on sub-5 nm ultrafine iron oxide nanoparticles (uIONP), featuring an anti-biofouling coating to prevent non-specific macrophage uptake and an M2-specific peptide ligand (M2pep) for active targeting of M2 TAMs.
View Article and Find Full Text PDFN-oxide-Functionalized Bipyridines as Strong Electron-Deficient Units to Construct High-Performance n-Type Conjugated Polymers.
Adv Sci (Weinh)
January 2025
Key Laboratory of Functional Molecular Solids, Ministry of Education, School of Chemistry and Materials Science, Anhui Normal University, No.189, Jiuhua South Road, Wuhu, Anhui, 241002, China.
Developing low-cost unipolar n-type organic thin-film transistors (OTFTs) is necessary for logic circuits. To achieve this objective, the usage of new electron-deficient building blocks with simple structure and easy synthetic route is desirable. Among all electron-deficient building units, N-oxide-functionalized bipyridines can be prepared through a simple oxidized transformation of bipyridines.
View Article and Find Full Text PDFA Cu-salen-based conjugated microporous polymer catalyst for -formylation of CO under mild conditions.
Chem Commun (Camb)
January 2025
Hunan Provincial Key Laboratory of Micro & Nano Materials Interface Science, College of Chemistry and Chemical Engineering, Central South University, Changsha, Hunan 410083, China.
A heterogeneous salen-based conjugated microporous polymer catalyst (CMP@Cu-salen) is prepared by a one-pot method for -formylation of amines with CO. The uniformly dispersed Cu-salen site and porous structure facilitates the enrichment of CO and transfer of substrates and the transformation. Our CMP@Cu-salen shows excellent catalytic performance (conversion: 99%, selectivity: 90%) for formylation of -methylaniline under mild conditions (0.
View Article and Find Full Text PDFSynthesis and Optoelectronic Characterizations of Conjugated Polymers Based on Diketopyrrolopyrrole and 2,2'-(thieno[3,2-b]thiophene-2,5-diyl)diacetonitrile Via Knoevenagel Condensation.
Macromol Rapid Commun
January 2025
State Key Laboratory of Applied Organic Chemistry (SKLAOC), Key Laboratory of Special Function Materials and Structure Design, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, 730000, China.
Conjugated polymers have attracted extensive attention as semiconducting materials in wearable and flexible electronics. In this study, we utilize atom-economical Knoevenagel reaction to construct two conjugated polymers, PTDPP-CNTT and PFDPP-CNTT, based on dialdehyde-thiophene/furan-flanked diketopyrrolopyrrole (DPP) and 2,2'-(thieno[3,2-b]thiophene-2,5-diyl)diacetonitrile (CNTT). The resulting polymers exhibited suitable highest occupied molecular orbital/lowest unoccupied molecular orbital (HOMO/LUMO) energy levels, small bandgaps, and broad UV-vis-NIR absorptions (≈400-1000 nm), endowing them with photothermal and balanced ambipolar semiconducting properties with hole and electron mobilities over 10 cmVs.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!