As a variant of Vaccinia virus, Buffalopox virus is known to cause Buffalopox disease. In recent times, sporadic outbreaks of the infection in humans have been reported, especially in the endemic countries of Southeast Asia. Though mortality has not been high, associated morbidity is significant. Due to waning cross-protective immunity against smallpox, Buffalopox virus is one of the several orthopox viruses likely to emerge or reemerge. To combat this virus, early recognition, isolation, and management of the infection in animals and humans is of prime importance. In addition, vaccination in animals and humans at risk of acquiring infection is essential as a means of limiting animal-to-animal and animal-to-human spread of the virus. With this in mind, a collaborative approach between the animal and human health sectors is indispensable.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.idnow.2024.104954 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Buffalopox: An emerging zoonotic challenge.
Infect Dis Now
September 2024
Department of Neurovirology, National Institute of Mental Health and Neurosciences (NIMHANS), Bengaluru, Karnataka 560029, India. Electronic address:
As a variant of Vaccinia virus, Buffalopox virus is known to cause Buffalopox disease. In recent times, sporadic outbreaks of the infection in humans have been reported, especially in the endemic countries of Southeast Asia. Though mortality has not been high, associated morbidity is significant.
View Article and Find Full Text PDFNatural Immunomodulatory Agents as a Complementary Therapy for Poxviruses.
Adv Exp Med Biol
May 2024
Pharmacology Department, National Research Centre (NRC), 33 El Buhouth St. (Former El-Tahrir St.), Dokki, Cairo, 12622, Egypt.
Article Synopsis
- - Poxviruses, like monkeypox virus (MPXV), target both innate and adaptive immune responses, making it crucial to find effective treatments as there are currently no approved options for poxvirus infections.
- - Natural bioactive compounds, particularly polyphenolics (like rosmarinic and caffeic acids), are promising as they exhibit antioxidant, anti-inflammatory, and antiviral properties that may help combat poxviruses.
- - Research into traditional plants and their extracts, alongside the need for further molecular studies, is essential to fully understand and validate the antiviral effects of these natural components against poxviruses.
Hesperetin blocks poxvirus replication with a low tendency to select for drug-resistant viral variants.
J Med Virol
April 2024
National Centre for Veterinary Type Cultures, ICAR-National Research Centre on Equines, Hisar, India.
In this study, we demonstrated the antiviral efficacy of hesperetin against multiple poxviruses, including buffalopox virus (BPXV), vaccinia virus (VACV), and lumpy skin disease virus (LSDV). The time-of-addition and virus step-specific assays indicated that hesperetin reduces the levels of viral DNA, mRNA, and proteins in the target cells. Further, by immunoprecipitation (IP) of the viral RNA from BPXV-infected Vero cells and a cell-free RNA-IP assay, we demonstrated that hesperetin-induced reduction in BPXV protein synthesis is also consistent with diminished interaction between eukaryotic translation initiation factor eIF4E and the 5' cap of viral mRNA.
View Article and Find Full Text PDFBuffalopox: An emerging cutaneous disease in humans.
J Eur Acad Dermatol Venereol
December 2023
Center of Clinical Studies, Houston, Texas, USA.
Background: Buffalopox virus (BPXV) infection is an under-recognized zoonotic disease associated with recently reported outbreaks in humans in South Asia. It is frequently isolated from skin lesions in cattle and buffalos, and can be transmitted to humans by direct contact with the skin of infected animals and fomites. Very little data exist to inform treatment guidelines.
View Article and Find Full Text PDFA case of human buffalopox in Malappuram, India: The role of mpox surveillance in 2022.
J Med Virol
February 2023
Indian Council of Medical Research-National Institute of Virology, Pune, Maharashtra, India.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!