There has been limited research on external browning (EB) of walnut. This work discovered 1888 metabolites and 34 anthocyanins in walnut pellicles (WPs) after three drying methods using widely-targeted and anthocyanin-targeted metabolomics. Based on OPLS-DA and correlation analysis, 64 temperature-responsive metabolites (TRMs; 13 anthocyanins and 51 flavonoids) were identified as critical components in relation to EB. Notably, 14 flavonoids exhibited a strong positive correlation (r > 0.9) with the browning index (BI), with upregulation of >60% after browning. Most of the identified anthocyanins were negatively linked with BI because of degradation (>45%), with correlation coefficients ranging from 0.75 to 0.97. Furthermore, anthocyanidin reductase and laccase were the two key enzymes involved in the EB of WPs, with their activities increasing by 10.57-fold and 1.32-fold, respectively, with increasing drying temperature. A metabolic pathway network of the TRM was built to provide insights into the potential mechanisms underlying EB in WPs.
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http://dx.doi.org/10.1016/j.foodchem.2024.140440 | DOI Listing |
Ophthalmic Plast Reconstr Surg
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Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts.
A 73-year-old male with a history of incidentally diagnosed Paget disease of bone affecting the skull and left orbit 2 years prior presented with 3 months of vision loss, proptosis, and periorbital swelling of the OS. Examination showed best-corrected Snellen visual acuity of 20/150 in the affected eye, intact motility, 7 mm of relative proptosis, significant dilated and tortuous "corkscrew" conjunctival vessels, serous choroidal and retinal detachments, optic nerve hyperemia, and venous tortuosity and dilation. Although the bony lesions in the left orbit were stable from 1 year prior on imaging, the diagnostic angiogram demonstrated osseous blush and hypervascularity of the lesion.
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Springer Nature, Mairangi Bay, Private Bag 65901, Auckland, 0754, New Zealand.
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Health through Flourishing (HtF) program, Department of Psychiatry, Massachusetts General Hospital, Boston, MA, United States.
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J Bone Joint Surg Am
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Department of Orthopedic Surgery, Warren Alpert Medical School, Brown University, Providence, Rhode Island.
➢ Jehovah's Witnesses refuse allogeneic blood products based on religious beliefs that create clinical, ethical, and legal challenges in orthopaedic surgery, requiring detailed perioperative planning and specific graft selection.➢ Detailed perioperative planning is particularly important for procedures with high intraoperative blood loss.➢ Graft selection must align with Jehovah's Witnesses patients' religious beliefs, with options including autografts, allografts, and synthetic materials; this requires shared decision-making between the patient and surgeon.
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Author Affiliations: Prevention Research Center, Brown School, Washington University in St. Louis, St. Louis, Missouri (Allen and Crenshaw); Department of Health Policy and Organization, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama (Fifolt); School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama (Erwin); Research and Evaluation, Public Health Accreditation Board, Alexandria, Virginia (Lang, Belflower Thomas, and Kuehnert); and Lipstein Distinguished Professor of Public Health, Prevention Research Center, Brown School, and Alvin J. Siteman Cancer Center and Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine; Washington University in St. Louis, St. Louis, Missouri (Brownson).
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