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Basic Science and Pathogenesis.
Alzheimers Dement
December 2024
National Center for Geriatrics and Gerontology, Obu, Aichi, Japan.
Background: A polygenic risk score (PRS) estimates an individual's genetic liability for diseases based on accumulated genetic variations. While the PRS has been shown to contribute to the prediction of dementia risk, its utility in predicting the effectiveness of multifactorial interventions to reduce the risk of dementia remains unclear.
Methods: A genome-wide association study (GWAS) was conducted to identify dementia-related traits in the Japanese population.
Basic Science and Pathogenesis.
Alzheimers Dement
December 2024
Physiopathology in Aging Laboratory (LIM-22), University of Sao Paulo Medical School, São Paulo, São Paulo, Brazil.
Background: Lewy body disease (LBD) is a neurodegenerative condition marked by the accumulation of neuronal alpha-synuclein, leading to both Parkinson's disease and Lewy body dementia. It is regarded as the second most common neurodegenerative disease associated with aging. However, there is limited knowledge of LBD prevalence in the general population, particularly among non-whites.
View Article and Find Full Text PDFClinical Manifestations.
Alzheimers Dement
December 2024
Alzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, Netherlands.
Background: Alzheimer's disease (AD) causes increasing cognitive and functional impairments, and both are therefore important outcome measures for intervention studies. Cognition and everyday functioning are often used interchangeably, yet the extent of their relationship is still unclear. We therefore aim to assess the relationship between different cognitive domains and everyday functioning across the AD spectrum.
View Article and Find Full Text PDFClinical Manifestations.
Alzheimers Dement
December 2024
Department of Medicine, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI, USA.
Background: Frequent and remote cognitive assessment may improve sensitivity to subtle cognitive decline associated with preclinical Alzheimer's disease (AD). However, repeated testing can result in unintended inflation of scores, due to practice effects. The objective of this study is to evaluate the extent of sessions with non-identical stimuli on performance and determine if study design or amyloid PET status moderates the impact of practice.
View Article and Find Full Text PDFClinical Manifestations.
Alzheimers Dement
December 2024
Hospital de Clínicas de Porto Alegre, Porto Alegre, Rio Grande do Sul, Brazil.
Background: Mild Behavioral Impairment (MBI) is a construct developed to capture neuropsychiatric symptoms in individuals in early stages of neurodegenerative diseases. The assessment of MBI in individuals with preclinical cognitive manifestations in Brazil is still quite limited. The aim of this study is to evaluate the MBI-Checklist (MBI-C) in individuals with subjective cognitive decline (SCD) and mild cognitive impairment (MCI) in the Brazilian Subjective Cognitive Decline (BRASCODE) cohort in southern Brazil.
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