Exploring emotional distress symptom clusters in young adults with childhood traumatic brain injury.

Background: Depression, anxiety, and stress are persistent and co-occurring symptoms in survivors of childhood traumatic brain injury (TBI), and often impact on health-related quality of life (HRQoL). This paper explored emotional distress symptom clusters and associated factors in young adults with childhood TBI.

Methods: We included 54 young adults who sustained mild ( = 14), moderate ( = 27), and severe ( = 13) childhood TBI, at 20 years post-injury. The Depression Anxiety Stress Scale was administered. Cluster group membership was identified using two-step clustering and hierarchical clustering methods, and associated factors were assessed with multiple regression models.

Results: Two symptom cluster groups were identified, including a 66%) and an 33%) group with the latter showing significantly higher symptoms of depression, anxiety, and stress (all  < .001). Elevated Distress group membership was linked to tobacco use and poor sleep quality, while poor HRQoL was associated with younger age at injury and Elevated Distress group membership.

Conclusions: Using cluster methodology, we showed that one-third of young adults with childhood TBI had elevated emotional distress symptoms. This underscores the complex emotional profile of this subgroup and the need for assessment, analysis, and treatment methods that target a range of symptoms rather than relying on single-diagnostic protocols.

Abbreviations: Analysis of Variance; Computed Tomography; Depression Anxiety Stress Scale; Glasgow Coma Scale; Human Research Ethics Committee; Health-Related Quality of Life; International Business Machines Corporation; Magnetic Resonance Imaging; Post-Traumatic Amnesia; Quality of Life; Quality of Life after Brain Injury Scale; Research Electronic Data Capture; Socioeconomic Status; Statistical Package for the Social Sciences; Traumatic Brain Injury.