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Efficacy of nebulized GM-CSF inhalation in preventing oral mucositis in patients undergoing hematopoietic stem cell transplantation: A retrospective study.
Heliyon
October 2024
Department of Hematology, The Second Affiliated Hospital of Chongqing Medical University, No.288, Tian-Wen Road, Chongqing, 40000, China.
Article Synopsis
- The study aimed to evaluate the effectiveness of inhaling oxygen atomized granulocyte-macrophage colony-stimulating factor (GM-CSF) in preventing oral mucositis in patients after hematopoietic stem cell transplantation.
- Data was collected from 143 patients treated at the hospital over two years, dividing them into an observation group (who received GM-CSF) and a control group (who did not) while assessing various factors like pain and infection status.
- The patient demographics included a diverse range of ages and conditions, revealing a mix of autologous and allogeneic transplantations, and highlighting the complexities of treating oral mucositis in this population.
Inhaled molgramostim therapy for the treatment of autoimmune pulmonary alveolar proteinosis (aPAP): a plain language summary of the IMPALA trial.
Hosp Pract (1995)
August 2024
Translational Pulmonary Science Center, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
In mouse model of mixed granulocytic asthma with corticosteroid refractoriness, Bronchom mitigates airway hyperresponsiveness, inflammation and airway remodeling.
Mol Med
August 2024
Drug Discovery and Development Division, Patanjali Research Foundation, Haridwar, India.
Background: Asthma is a heterogeneous, inflammatory disease with several phenotypes and endotypes. Severe asthmatics often exhibit mixed granulocytosis with reduced corticosteroid sensitivity. Bronchom is a newly developed Ayurvedic prescription medicine, indicated for the treatment of obstructive airway disorders.
View Article and Find Full Text PDFNebulized granulocyte macrophage-colony stimulating factor to stabilize lung function in nontuberculous mycobacteria pulmonary disease in cystic fibrosis.
Pediatr Pulmonol
November 2024
Department of Pharmacy, Oregon Health & Science University, Portland, Oregon, USA.
An antibacterial, multifunctional nanogel for efficient treatment of neutrophilic asthma.
J Control Release
August 2024
The Medical Basic Research Innovation Center of Airway Disease in North China, Ministry of Education, and College of Basic Medical Sciences, Jilin University, Changchun 130021, China.. Electronic address:
Article Synopsis
- * Researchers developed composite nanogels (ECAT) using chitosan and an antimicrobial agent, which effectively inhibited the growth of harmful bacteria and mucin aggregation in laboratory tests.
- * In animal studies, these ECAT nanogels showed promise by reducing inflammation and airway hyperresponsiveness in a model of neutrophilic asthma, indicating their potential as an effective treatment option.
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