AI Article Synopsis
- T cell receptors (TCRs) are specific markers on T cells that help them recognize and bind to foreign antigens, playing a crucial role in immune responses.
- TCRs rely on the CD3 molecule for proper signaling and structural stability, forming a TCR-CD3 complex that is essential for T cell activation.
- Research on CD3 subunits' roles can enhance our understanding of immune system diseases and lead to new targeted therapies.
Article Abstract
T cell receptor (TCR) is a kind of surface marker that are specific to T cells. The TCR regulates T cell function and participates in the body's immunological response to prevent immune dysregulation and inflammatory reactions by identifying and binding exogenous antigens. Due to its brief intracellular segment, TCR requires intracellular molecules to assist with signaling. Among these, the CD3 molecule is one of the most important. The CD3 molecule involves in TCR structural stability as well as T cell activation signaling. A TCR-CD3 complex is created when TCR and CD3 form a non-covalent bond. Antigen recognition and T cell signaling are both facilitated by the TCR-CD3 complex. When a CD3 subunit is absent, a TCR-CD3 complex cannot form, and none of the subunits is transported to the cell surface. Thus, T cells cannot develop. Consequently, research on the physiological functions and potential pathogenicity of CD3 subunits can clarify the pathogenesis of immune system diseases and can offer fresh approaches to the treatment of it. In this review, the structure and function of the TCR-CD3 complex in the immune system was summarized, the pathogenicity of each CD3 subunit and therapeutic approaches to related diseases was explored and research directions for the development of new targeted drugs was provided.
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| http://dx.doi.org/10.1016/j.bcp.2024.116441 | DOI Listing |
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