AI Article Synopsis
- Liu et al. identify a synthetic diterpenoid called Q29 that inhibits hedgehog signaling by blocking cholesterol modification of smoothened (SMO).
- Q29 has shown effectiveness in suppressing tumor cell growth in both laboratory settings (in vitro) and in living organisms (in vivo).
- The compound also has potential to overcome resistance to existing SMO inhibitors, making it a promising candidate for cancer treatment.
Article Abstract
In this issue of Cell Chemical Biology, Liu et al. report the identification of Q29, a synthetic diterpenoid that blocks covalent cholesterol modification of smoothened (SMO) and inhibits hedgehog signaling. Q29 is capable of suppressing tumor cell growth, both in vitro and in vivo, and overcoming resistance to SMO inhibitors.
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| http://dx.doi.org/10.1016/j.chembiol.2024.06.005 | DOI Listing |
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