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MicroRNA:Siglec crosstalk in cancer progression. | LitMetric

MicroRNA:Siglec crosstalk in cancer progression.

Curr Opin Chem Biol

School of Life and Medical Sciences, University of Hertfordshire, Hatfield, AL10 9AB, UK. Electronic address:

Published: August 2024

Aberrant Siglec expression in the tumour microenvironment has been implicated in tumour malignancies and can impact tumour behaviour and patient survival. Further to this, engagement with sialoglycans induces masked antigen recognition and promotes immune evasion, highlighting deregulated immune function. This necessitates the elucidation of their expression profiles in tumour progression. MicroRNAs (miRNAs) mediated targeting represents a novel approach to further elucidate Siglec potential and clinical relevance. Although miRNA activity in Siglec expression remains limited, we highlight current literature detailing miRNA:Siglec interactions within the tumour landscape and provide insights for possible diagnostic and therapeutic strategies in targeting the Siglec/sialic acid axis.

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Source
http://dx.doi.org/10.1016/j.cbpa.2024.102502DOI Listing

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