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A new scoring in differential diagnosis: multisystem inflammatory syndrome or adenovirus infection?
Turk J Med Sci
December 2024
Department of Pediatrics Cardiology, Kayseri City Hospital, Kayseri, Turkiye.
Background/aim: Differentiating multisystem inflammatory syndrome in children (MIS-C) from adenovirus infection (AI) can be challenging due to similar clinical and laboratory findings. This study aimed to identify distinguishing characteristics and develop a scoring system to facilitate accurate diagnosis.
Materials And Methods: A comprehensive review of medical records was undertaken for 108 MIS-C patients and 259 patients with confirmed AI.
Possible viral agents to consider in the differential diagnosis of blepharoconjunctivitis.
World J Virol
December 2024
Department of Ophthalmology, University Hospital of Udine, Udine 33100, Italy.
Background: Blepharoconjunctivitis poses a diagnostic challenge due to its diverse etiology, including viral infections. Blepharoconjunctivits can be acute or chronic, self-limiting, or needing medical therapy.
Aim: To review possible viral agents crucial for accurate differential diagnosis in cases of blepharoconjunctivitis.
Bleb-related endophthalmitis during an epidemic of viral keratoconjunctivitis.
BMJ Case Rep
December 2024
Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, Delhi, India.
Article Synopsis
- North India experiences an annual outbreak of viral conjunctivitis during the monsoon season, impacting a large number of people, most of whom recover without treatment.
- Patients with a history of trabeculectomy (eye surgery for glaucoma) are at increased risk as conjunctivitis can lead to serious complications like blebitis and bacterial/fungal infections.
- It's crucial to educate these patients about the conjunctivitis outbreak and the warning signs that require immediate medical attention to prevent complications.
Evaluating anterior corneal surface using Placido ring mires for irregular astigmatism in refractory corneal subepithelial infiltrates after adenoviral conjunctivitis.
BMC Ophthalmol
November 2024
Nagata Eye Clinic, 1147 Kitayamada Hohrai, Nara-City, 6310844, Nara, Japan.
Article Synopsis
- Corneal subepithelial infiltrates (SEIs) can lead to vision problems in patients with adenoviral keratoconjunctivitis (AKC), often causing irregular astigmatism that is overlooked.
- An 8-year-old girl with AKC experienced recurring vision issues despite treatment, revealing that her vision loss was due to an irregular corneal surface rather than corneal opacity.
- Treatment with 0.1% tacrolimus eye drops proved effective in addressing both the corneal opacity and the irregular surfaces, emphasizing the importance of using Placido ring topography for diagnosis and monitoring.
Human adenovirus type 4 (HAdV-4) associated acute respiratory tract infection in children & genetic characteristics of HAdV-4 in China: a prospective multicenter study.
BMC Infect Dis
September 2024
Beijing Key Laboratory of Pediatric Respiratory Infection diseases, Key Laboratory of Major Diseases in Children, Ministry of Education, National Clinical Research Center for Respiratory Diseases, Research Unit of Critical Infection in Children, Chinese Academy of Medical Sciences, 2019RU016, Laboratory of Infection and Virology, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, 100045, China.
Article Synopsis
- Human adenovirus (HAdV) is a significant cause of acute respiratory infections in children in China, particularly HAdV-4, which has resulted in deaths but has been poorly studied.
- From 2017 to 2020, researchers analyzed respiratory samples from 2,847 children hospitalized with acute respiratory infections, finding that HAdV-4 was present in 0.39% of samples, mainly causing fever and cough, with some severe cases requiring intensive care.
- The genetic study revealed that the strains of HAdV-4 from this research are closely related to others in China, showing some mutations in capsid proteins but no signs of new recombination, indicating stability in the virus's genetic makeup.
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