AI Article Synopsis

  • Thrombotic thrombocytopenic purpura (TTP) is a severe condition characterized by symptoms like anemia, fever, neurological issues, low platelet count, and kidney problems.
  • A 27-year-old woman with TTP was admitted after experiencing unresponsiveness post-C-section, showing signs of acute kidney injury and severe complications.
  • The patient underwent eight cycles of therapeutic plasma exchange (TPE), resulting in significant improvement in her blood and kidney function, highlighting TPE's potential as a life-saving treatment for TTP.

Article Abstract

Thrombotic thrombocytopenic purpura (TTP) is a life-threatening disease present with the classic pentad of microangiopathic hemolytic anemia (MAHA), fever, neurologic changes, thrombocytopenia, and renal dysfunction. In a diagnostic dilemma, therapeutic plasma exchange (TPE) is a choice of life-saving intervention. In this, we assess the efficacy of TPE in a suspected case of post-partum TTP. A 27 years old female was admitted in an emergency on day 8 after a lower segment cesarian section (LSCS) with unresponsive behavior for 3 days and with TTP. She was normal 32 days back with her second, 7-month pregnancy. Ultrasonography (USG) showed an umbilical cord around the neck of the baby. On the fifth post-operative day, she was shifted to emergency with fever, generalized anasarca, gastrointestinal tract (GI) bleeding, low platelet count, and low Hb, with a poor Glasgow coma scale (GCS) of 6. On the bases of serum urea and serum creatinine, she presented acute kidney injury with encephalopathy. At emergency, she was unresponsive to mechanical ventilation and supportive treatment; hence, therapeutic plasma exchange was performed. After eight TPE cycles, the patient presented with an improved hematological and renal profile with good GCS. TPE is helpful and life-saving for suspected TTP patients with AKI.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11254058PMC
http://dx.doi.org/10.4103/jfmpc.jfmpc_1044_23DOI Listing

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